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网氨酸通过独立于cuproptosis的机制减轻NSC319726引起的精子生成功能障碍

Haisheng Yi¹, Tong Chen², Guitian He²

¹Department of Andrology, The First Hospital of Jilin University, Jilin University, Changchun, 130012, China.

Cell biology and toxicology

|May 1, 2024

概括

铜离子体NSC319726通过破坏精子生成和雄激素合成,导致男性生殖毒性. 然而,视网酸可能为相关的精子生成障碍提供潜在的治疗方法.

科学领域:

生殖毒理学生殖毒理学
癌症治疗的副作用癌症治疗的副作用
毒性的细胞机制.

背景情况:

铜离子体NSC319726在癌症治疗中表现有前途.
目前尚不清楚NSC319726对男性生育能力的潜在不良影响.

研究的目的:

研究NSC319726对男性生殖系统的影响.
阐明NSC319726引起的生殖毒性背后的机制.

主要方法:

雄性小鼠被暴露在NSC319726中长达5周.
评估丸指数,精子生成,精子参数,荷尔蒙水平和丸组织学.
研究了铜离子,cuproptosis和视网膜酸信号传递的作用.

主要成果:

NSC319726暴露减少了丸指数,受损的精子生成,以及受损的丸结构.
它破坏了精子生产,雄激素合成和血液丸屏障的完整性.
升高的丸铜诱导了cuproptosis;铜化提供了部分恢复.
降低的视网醇脱酶10 (RDH10) 抑制了视网酸的产生,损害了变的启动.

结论:

NSC319726表现出显著的男性生殖毒性,可能是通过铜诱导的cuproptosis和受损的视网膜酸信号.
铜化和网红酸的使用显示了减轻NSC319726引起的生殖损伤的潜力.
在接受NSC319726.6治疗的患者中,酸可能是男性不孕症的治疗策略.

关键词:

辅助药物辅助药物是一种辅助药物.铜离子体是一种铜离子体.这种疾病叫做cuproptosis.美国国家安全委员会31972626号雷蒂诺酸是什么意思雷蒂诺酸是什么意思精子发生的功能障碍.

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