翻译双孔PBPK模型用于描述不同大小内源和外源蛋白的全身配置

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Updated: Jun 27, 2025

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

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Shufang Liu1, Yingyi Li2, Zhe Li2

  • 1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, 455 Pharmacy Building, Buffalo, NY, 14214-8033, USA. shufangl@buffalo.edu.

Journal of pharmacokinetics and pharmacodynamics
|May 1, 2024
PubMed
概括

一个新的双孔生理学基础的药理动力学 (PBPK) 模型准确地预测了跨物种的多种蛋白疗法的行为. 这种转化模型通过表征蛋白质配置和告知剂量策略来增强生物的发展.

关键词:
专辑中的专辑蛋白.抗体碎片的抗体碎片单克隆抗体是一种单克隆抗体.基于生理学的药理动力学 (PBPK) 建模.蛋白质治疗药物 蛋白质治疗药物两个孔的理论理论.

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