中枢敏感性显著恶化功能和解释的自我报告的疾病活动在初级Sjögren综合征
Aylin Sariyildiz1, Ilke Coskun Benlidayi2, Ayşegül Yetişir3
1Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cukurova University, Adana, Turkey. aylingoksen@hotmail.com.
Clinical rheumatology
|May 1, 2024
概括
中心敏感性显著影响原发性Sjögren综合征 (pSS) 患者,影响其功能和疾病活动解释. 解决中央敏感性是有效的pSS管理和治疗评估的关键.
科学领域:
- 类风湿病学 类风湿病学
- 神经科学是一个神经科学.
- 临床医学 临床医学
背景情况:
- 中央敏感性在肌肉骨疾病中起着关键作用.
- 它对原发性Sjögren综合征 (pSS) 疾病活动和功能障碍的影响尚不清楚.
研究的目的:
- 调查中心敏感化对PSS患者疾病活动和功能障碍的影响.
- 评估pSS中中央敏感化和各种健康相关参数之间的关系.
主要方法:
- 中央敏感化库存 (CSI) 在60名pSS患者中选中央敏感性.
- 评估了疾病活动 (ESSPRI,ESSDAI),功能 (HAQ-DI),生活质量 (SF-36),睡眠 (JSS) 和心理健康 (HADS).
- 回归分析评估了中央敏感化对测量参数的影响.
主要成果:
- 在65%的pSS患者中存在中央敏感性.
- 中心敏感的患者在HAQ-DI,ESSPRI,HADS,JSS和SF-36得分中表现较差.
- CSI得分与ESSPRI,JSS,HAQ-DI和HADS正相关,并且与HAQ-DI和ESSPRI独立相关.
结论:
- 中心敏感性显著影响pSS的功能和自我报告的疾病活动.
- 它的高流行率和与关键结果的独立关联凸显了它在PSS管理中的重要性.
- 考虑中央敏感性对于有效的治疗策略和评估pSS患者的反应至关重要.
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