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通过TRIM32对对结肠直肠癌的影响和机制的研究

Xiaohua Cai¹, Yintong Su¹, Jiayu Ning¹

¹Department of Hygiene Inspection & Quarantine Science, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.

Biological trace element research

|May 1, 2024

概括

(Se) 补充剂通过降低TRIM32.2的调节来抑制结直肠癌 (CRC) 的生长. 这项研究探讨了Se Se.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
营养科学营养科学

背景情况:

(Se) 摄入量与结直肠癌 (CRC) 风险有负相关性.
基于Se对CRC发育的影响的精确分子机制尚不清楚.
了解Se在CRC中的治疗潜力和抗瘤机制至关重要.

研究的目的:

评估 (Se) 对结直肠癌 (CRC) 的治疗作用.
研究Se补充剂对CRC的抗瘤作用.
阐明Se影响CRC进展的分子机制.

主要方法:

在体外测试:殖民地形成,细胞,Transwell迁移和流细胞计.
在体内实验评估瘤生长抑制.
对TRIM32表达和生存的TCGA和GEO数据集的生物信息分析.
RNA测序和西方抹黑用于验证基因表达变化.

主要成果:

在CRC细胞系 (HCT116,SW480) 中,Se显著抑制了增殖并诱导了细胞亡 (apoptosis).
在体内,Se对瘤生长表现出显著的抑制作用.
在CRC组织中TRIM32的表达很高,并且与预后不佳有关.
在HCT116细胞中的TRIM32表达得到了下调.
结合Se治疗和TRIM32倒置协同抑制了CRC细胞的生长,迁移和诱导的亡.

结论:

(Se) 对结直肠癌 (CRC) 具有治疗潜力.
Se通过降低TRIM32表达的调节来抑制CRC细胞的生长和增殖.
针对TRIM32与Se补充剂一起,可能为CRC提供一种新的治疗策略.

关键词:

结肠直肠癌是一种癌症.机制研究研究机制研究是一种.在TRIM32中,我们可以使用TRIM32.

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