在孤立严重创伤性脑损伤期间早期微粒子释放的影响:与凝血病和死亡率的相关性
Venencia Albert1, Arulselvi Subramanian1, Hara Prasad Pati2
1Departments of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, AIIMS, New Delhi, India.
Neurology India
|May 1, 2024
概括
严重创伤性脑损伤 (sTBI) 增加了血小板衍生的微粒 (PMP) 和内皮细胞衍生的微粒 (EMP). 低PMP水平与STBI患者的早期凝血病有关.
科学领域:
- 创伤研究研究创伤研究
- 血液学 血液学 血液学
- 血管生物学 血管生物学
背景情况:
- 微粒子 (MP) 与血栓形成和内皮功能障碍有关.
- 它们在早期凝血病和严重创伤性脑损伤 (sTBI) 的结果中的作用尚不清楚.
研究的目的:
- 在sTBI患者中量化循环MP亚型 (血小板衍生,内皮细胞衍生,组织因子载体).
- 分析与早期凝血病,血栓生成和死亡率的相关性.
主要方法:
- 对STBI患者的前性研究,收集输血前的血液.
- 流式细胞计量用于MP的计数和表征.
- 埃利萨测试用于血-抗血复合物 (TAT) 水平.
- 与健康对照组 (HC) 的比较.
主要成果:
- sTBI患者的血小板衍生的微粒 (PMP) 和内皮细胞衍生的微粒 (EMP) 与HCs相比增加.
- 带有组织因子的MPs (TFMPs) 没有显著差异.
- 在41.6%的患者中观察到早期TBI相关的凝血病 (TBI-AC).
- 与没有TBI-AC的患者相比,TBI-AC的患者的PMP和EMP数量较低.
结论:
- 孤立的sTBI会导致细胞活化增加和产生血凝性MP.
- 与TBI相关的凝血病与较低的血PMP计数有关.
- 低PMP可能有助于TBI-AC的发展.
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