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Updated: Jun 27, 2025

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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一个针对HLA-E的TCR双特异性分子重定向T细胞对抗Mycobacterium tuberculosis的免疫力

Rachel L Paterson1, Marco P La Manna2,3, Victoria Arena De Souza1

  • 1Immunocore Ltd., Abingdon, Oxfordshire OX14 4RY, United Kingdom.

Proceedings of the National Academy of Sciences of the United States of America
|May 1, 2024
PubMed
概括

这项研究引入了一种新的基于T细胞受体 (TCR) 的双特异分子,向呈现Mycobacterium结核病的HLA-E. 这种方法通过克服HLA多态性来增强T细胞对结核病的免疫力,适用于更广泛的患者群体.

关键词:
在HLA-E的基础上,HLA-ET细胞受体受体的 T 细胞受体.免疫疗法 免疫疗法结核病是一种肺结核病.

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