多模式MRI揭示了维持人类意识清醒的脑干连接
Brian L Edlow1,2, Mark Olchanyi1,3, Holly J Freeman1,2
1Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Science translational medicine
|May 1, 2024
概括
研究人员绘制了人类大脑的兴奋网络,确定了大脑干和丘脑中的关键节点. 这项研究揭示了皮质下刺激网络如何与皮质意识网络连接以保持清醒.
科学领域:
- 神经科学是一个神经科学.
- 人类意识研究 人类意识研究
- 大脑网络绘制地图
背景情况:
- 意识包括唤醒 (清醒) 和意识.
- 对于意识的皮质网络是很好地绘制的.
- 维持兴奋的皮质下网络仍然不完全理解.
研究的目的:
- 在人类大脑中绘制下皮层默认上升兴奋网络 (dAAN) 的连接.
- 了解这个网络是如何维持清醒的.
- 调查它与皮质默认模式网络 (DMN) 的关系,以提高认识.
主要方法:
- 综合性ex vivo扩散MRI来自三个具有免疫组织化学的人类大脑.
- 利用确定性和概率学曲谱来分析连接性.
- 分析了来自人类连接体项目的体内7-特斯拉静止状态fMRI数据.
主要成果:
- 在大脑干,下丘脑,丘脑和基本前脑中确定了dAAN节点.
- 揭示了连接dAAN节点和DMN节点的投影,关联和委托路径.
- 发现腹部 tegmental 区域作为连接兴奋和意识网络的枢纽.
结论:
- 为默认的上升兴奋网络建立了一个假定的神经解剖结构.
- 证明了皮质下唤醒和皮质意识网络的整合.
- 提供了对人类意识和清醒的神经基础的见解.
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