通过Arctium Lappa L进行免疫反应调节的综合机制. 基于微生物组和代谢学技术的果糖素
Lingyu Li1, Zhichang Qiu1,2, Xinyan Bai1,3
1Key Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong 271018, PR China.
Journal of agricultural and food chemistry
|May 1, 2024
概括
多糖 (ALP-1) 通过增强有益细菌和免疫标记物,增强小鼠的肠道免疫力和健康. 这项研究揭示了ALP-1
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- (Arctium lappa L.) 以其健康益处而闻名,其中多糖是主要活性化合物.
- 了解白多糖的免疫调节潜力对于功能性食品的开发至关重要.
研究的目的:
- 为了评估白多糖ALP-1的免疫调节作用.
- 阐明ALP-1对免疫系统和肠道健康作用的潜在机制.
主要方法:
- 多糖ALP-1的表征 (组成,分子量,链接分析).
- 将ALP-1口服给健康小鼠.
- 对结肠杯细胞,血清免疫球蛋白 (IgA,IgG),便分泌IgA,抗氧化酶和短链脂肪酸 (SCFA) 的评估.
- 对促/抗炎细胞因子,肠道微生物群结构和代谢物概况的分析.
主要成果:
- 服用ALP-1显著增加了结肠杯细胞,血清IgA和IgG以及便分泌IgA.
- ALP-1上调节了抗氧化酶,并促进了SCFA的产生.
- ALP-1调节了关键细胞因子 (IL-1β,IL-6,TNF-α,IFN-γ,IL-10),改变了肠道微生物群的组成,并影响了肠道微生物群介导的代谢途径.
结论:
- 的多糖类ALP-1在小鼠中显示出显著的免疫调节作用.
- ALP-1通过增强免疫反应,抗氧化能力和有益的肠道微生物群来促进肠道健康.
- 这些发现支持ALP-1作为改善免疫和肠道健康的功能成分的潜力.
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