一种新的草药成分缓解功能性便秘,减少胃肠道过境时间,改善成人肠道功能:一项双盲随机临床研究
Gaurav Singh1, Indresh Dixit2, Douglas Kalman3
1Department of General Medicine, Upendra Medicare, Varanasi, Uttar Pradesh, India.
Journal of the American Nutrition Association
|May 1, 2024
概括
这项研究表明,CL18100F4,一种草药混合物,有效治疗功能性便秘,改善成人生活质量. 它显示了胃肠道症状和整体幸福感的显著改善.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 草药是一种草药.
背景情况:
- 功能性便秘影响了相当一部分成年人群.
- 现有的治疗方法可能有局限性或副作用.
- 一项试点研究表明,CL18100F4具有缓解便秘的潜力.
研究的目的:
- 为了评估CL18100F4在更大的队列中的疗效和耐受性.
- 为了证实先前试点研究的积极结果.
- 评估CL18100F4对胃肠道和非胃肠道症状的影响.
主要方法:
- 随机,双盲,安慰剂对照试验,包括135名参与者 (25-60岁).
- 每天服用安慰剂,300毫克或500毫克CL18100F4补充剂60天.
- 主要结局:患者对便秘症状的评估 (PAC-SYM);次要结局:PAC-QOL,GSRS,GIT,CSBM和血清生物标志物.
主要成果:
- CL18100F4显著降低了PAC-SYM,PAC-QOL,GSRS的分数,并改善了CSBM (p<0.001).
- 观察到睡眠质量,抑郁和焦虑症状的改善.
- 在血清生物标志物 (IL-10,DAO,血清激素,胃素,IL-6,皮质醇,Zonulin) 中发现了显著的变化.
结论:
- CL18100F4是一种耐受且有效的功能性便秘治疗方法.
- 这种草药混合物缓解了胃肠功能障碍,并改善了相关的非胃肠道因素.
- 结果支持CL18100F4用于管理成人功能性便秘.
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