墨西哥老年人的认知功能在从SARS-CoV-2感染中恢复后6个月
Alberto Jose Mimenza-Alvarado1, Abdias Ambrosio-Palma1, Sara Gloria Aguilar-Navarro1
1Deparment of Geriatric Medicine & Neurology Fellowship, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico.
Revista espanola de geriatria y gerontologia
|May 1, 2024
概括
在重症监护室出院6个月后,超过一半的幸存下来严重COVID-19的老年人患有认知障碍 (CI). 感染严重程度是与SARS-CoV-2幸存者的长期认知衰退相关的主要因素.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 老年病的医生 老年病的医生
背景情况:
- SARS-CoV-2 感染与各种短期和长期并发症有关,包括抑郁症和认知障碍 (CI).
- 患有COVID-19后CI的老年人仍然没有充分的证据,需要对这一脆弱人群进行进一步的研究.
研究的目的:
- 为了评估60岁及以上的墨西哥成年人从SARS-CoV-2感染中恢复后的认知功能.
- 在这个群体中识别与认知障碍相关的因素.
主要方法:
- 一项前性观察队列研究使用蒙特利尔认知评估 (MoCA) 评估认知功能,并通过远程医疗评估功能状态.
- 分析了107名符合条件的患者 (平均年龄70岁),这些患者患有中度至重度的COVID-19,需要接受ICU治疗,在感染前具有认知健康.
- 考克斯回归模型被用来评估COVID-19和CI之间的关联,不包括先前存在的痴呆症,中风或痴呆症的患者.
主要成果:
- 在分析的患者中,有57%的患者 (107人中有61人) 呈现CI (MoCA得分<26) 在ICU出院6个月后.
- 与CI相关的因素包括感染严重程度 (RR 1.87),较低的教育水平 (RR 0.92) 和日常生活残疾活动 (RR 1.87).
- 延迟回忆,定向和语言领域在CI患者中受到影响最大.
结论:
- 由于SARS-CoV-2的原因,在ICU出院六个月后,很大一部分老年人会出现认知障碍.
- COVID-19的严重程度成为与这种ICU后队列认知障碍发展相关的主要因素.
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