瘤微环境的全面量化,以预测对免疫治疗的反应和儿科神经母细胞瘤的预后
Mingkun Song1, Yiming Sun2, Yikai Hu2
1Tianjin Institute of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Department of Immunology, Tianjin Medical University, Tianjin 300070, China; Department of Paediatrics, Tianjin Medical University General Hospital, Tianjin 300052, China; Department of Paediatric Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
International immunopharmacology
|May 1, 2024
概括
研究人员根据瘤微环境 (TME) 遗传特征确定了四种神经母细胞瘤亚型. 一个新的评分系统准确地预测了免疫治疗的预后和反应,指导了个性化癌症治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 瘤微环境 (TME) 对神经母细胞瘤治疗的有效性构成重大挑战.
- 了解TME的异质性对于开发有针对性的治疗策略至关重要.
研究的目的:
- 根据遗传特征对神经母细胞瘤TME亚型进行分类.
- 开发一种双重评分系统 (免疫评分和扩散评分) 用于预后和免疫治疗反应预测.
- 为了确定神经母细胞瘤的潜在治疗剂.
主要方法:
- 神经母细胞瘤TME的分类为四种亚型:免疫丰富,免疫沙漠,非增殖和纤维化.
- 使用分子特征开发和验证免疫评分和增殖评分.
- 在体内和体外实验评估药物疗效 (阿克西提尼布,BI-2536).
主要成果:
- 免疫评分与免疫治疗反应相关.
- 增殖分数作为神经母细胞瘤的独立和准确的预后生物标志物.
- 亚克西替尼诱导热和激活抗瘤免疫力;BI-2536导致神经母细胞瘤细胞中S相细胞循环停止.
结论:
- 开发的双重评分系统有效预测神经母细胞瘤的预后,并指导个性化治疗策略.
- 该系统有助于选潜在的治疗选择,包括阿克西替尼和BI-2536.
- 针对TME和利用新型评分系统为改善神经母细胞瘤管理提供了有前途的途径.
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