与疼痛调节相关的功能连接的年龄相关差异
Marian van der Meulen1, Katharina M Rischer1, Ana María González Roldán2
1Department of Behavioural and Cognitive Sciences, University of Luxembourg, Luxembourg.
Neurobiology of aging
|May 1, 2024
概括
老龄化会损害大脑的自然疼痛控制系统,增加慢性疼痛的风险. 老年人功能连接性降低,特别是在关键大脑区域之间,与分散注意力的疼痛缓解程度较低有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 疼痛研究 疼痛研究
背景情况:
- 衰老与内源性疼痛调节的减弱有关,这可能解释了老年人患慢性疼痛的更高发病率.
- 休息状态功能连接 (rsFC) 是研究疼痛调制中与年龄相关的神经变化的工具,尽管其具体作用尚不清楚.
- 之前的rsFC研究表明,随着年龄的增长,网络内连接性下降,但与疼痛调节的相关性需要调查.
研究的目的:
- 为了比较年轻人和老年人的疼痛调节脑区域内的rsFC.
- 为了研究rsFC与疼痛分散注意力的有效性之间的关系.
- 为了确定影响疼痛调节的特定与年龄相关的连接性变化.
主要方法:
- 在年轻和年长成年人群之间的疼痛调节大脑网络中rsFC的比较.
- 评估RSFC与缓解分心任务中的疼痛疗效之间的相关性.
- 分析特定的连接,包括周水管灰色,前带皮质,内膜和杏仁体.
主要成果:
- 在疼痛调节区域内观察到与年龄相关的功能连接强度的增加和减少.
- 确定了减少疼痛缓解和老年人连接能力下降之间的显著关联.
- 特别注意的是,水道灰色和右侧胰岛,ACC和右侧胰岛,ACC和左侧杏仁体之间的连接性下降.
结论:
- 大脑疼痛控制系统的功能完整性对于有效的疼痛调节至关重要.
- 老龄化损害了这个系统的功能连接,导致疼痛调节效率降低.
- 特定神经通路 (例如,ACC-桃体) 的与年龄相关的衰退可能是老年人疼痛控制受损的基础.
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