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银(I) 复合物与沃里可纳作为有前途的抗甘地菌剂

Mia Stanković¹, Sanja Skaro Bogojevic², Jakob Kljun³

¹University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia.

Journal of inorganic biochemistry

|May 1, 2024

概括

银(I) 复合物与伏利可纳 (vcz) 显示出对Candida菌的抗真菌活性增强. 这些新型化合物有效地抑制了真菌生长,菌形成和厄戈斯特醇合成,提供了有前途的新型抗真菌剂.

科学领域:

无机化学无机化学
药用化学医学化学
菌类学菌类学是指菌类学.

背景情况:

金属离子可以改变药物的特性.
沃里康纳 (vcz) 是一种抗真菌剂.
开发新的抗真菌药物对于对抗真菌感染至关重要.

研究的目的:

合成和表征银(I) 复合物与伏利可纳 (vcz).
评估这些新型复合物的抗真菌活性对抗Candida物种.
研究银(I) -vcz复合物的作用机制.

主要方法:

合成的银(I) 复合体与vcz.
使用质谱,IR,UV-Vis,NMR和单晶X射线衍射进行表征.
抗真菌活性测试 (MIC值),菌和生物膜抑制试验,欧戈斯特醇合成抑制试验和分子对接研究.

主要成果:

合成了三种具有扭曲四面体几何学的聚合银(I) -vcz复合体.
DFT计算表明DMSO中的线性物种.
与前期相比,银 (I) 复合体表现出增强的抗坎迪达活性,降低的MIC值,以及优异的叶抑制,生物膜形成和厄戈斯特醇合成.
分子对接证实了复合体对CYP51B的更好的抑制.

结论:

伏利可纳的银 (I) 复合物是有效的抗真菌剂,其活性比原始药物更强.
这些复合物显示出抑制Candida毒性因子和厄戈斯特醇生物合成的潜力.
开发的银{I) -vcz复合物代表了新的抗真菌疗法的有希望的候选人.

关键词:

抗坎迪达病毒活动.这是CYP51B.协调聚合物的聚合物 DFT计算的计算方法银(I) 复合体中的银.沃里康纳 (Voriconazole) 是一种可以

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