海洋养殖水域是另一个热带,用于创建和转移新的抗生素耐药性病原体基因组

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Yiwei Cai¹, Chunliang Chen¹, Tong Sun¹

¹Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Key Laboratory of City Cluster Environmental Safety and Green Development (Department of Education), School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou 510006, China.

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|May 1, 2024

概括

水产养殖环境是抗生素耐药性的热点. 研究显示,养水中含有各种病原体,抗生素耐药性基因和移动遗传元素,有助于耐药细菌的传播.

科学领域:

环境微生物学环境微生物学
水生生态系统水生生态系统
抗微生物耐药性抗微生物耐药性

背景情况:

全球水产养殖业的扩张增加了抗生素的使用,可能导致抗生素耐药细菌 (ARB) 和抗生素耐药基因 (ARG).
了解海洋养殖中病原体,ARG和移动遗传元素 (MGE) 的相互作用,对于评估环境风险至关重要.

研究的目的:

为了研究南中国水域的病原体,抗生素抵抗性和移动性.
分析这些成分之间的共发生模式,并确定抗生素耐药性的潜在储库.

主要方法:

使用了超基因组和16S rRNA基因测序分析.
在水产养殖和沿海水样本中对病原体,ARG和MGE的表征.

主要成果:

确定了207种病原体物种,在海洋养殖水域的流行率更高,包括许多不能培养的病原体.
检测到913种ARG亚型,主要是多药性耐药性基因,以及丰富的MGE (等离子体,整子体,转子体).
同时发生的网络分析表明,由于频繁的水平基因转移,病原体可能是多药性宿主.

结论:

渔业水域是ARG和MGE的重要储存库.
这些环境充当了抗生素耐药性病原体的出现和传播的滋生地.

关键词:

鱼类养殖水水养殖甲基基因组是指甲基因组中的一部分.移动机组 (Mobilome) 是一个移动机组.病原体基因组是一种病原体.抵抗力抵抗力抵抗力无法培养的病原体

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