一个基于深度学习的管道,用于开发多肋形状生成模型,使用人口百分位数或人体测量作为预测器
Yuan Huang1, Sven A Holcombe2, Stewart C Wang3
1Research Investigator in International Center for Automotive Medicine (ICAM), University of Michigan, USA.
概括
这项研究引入了一种新方法,使用人工智能生成现实的肋骨形状,这对于理解受伤风险和为不同人群创建准确的人体模型至关重要.
科学领域:
- 生物机械工程 生物机械工程
- 医学成像分析 医学成像分析
- 计算解剖学的计算解剖学
背景情况:
- 肋骨截面形状极大地影响机械对冲击的反应,影响受伤模式和风险.
- 对肋骨形状及其人体测量相关性的准确统计描述对于为特定的人口结构开发人体模型至关重要.
- 变化自编码器 (VAE) 显示了解剖形状生成的潜力,但它们用于控制或解释生成的形状需要进一步调查.
研究的目的:
- 从CT图像中开发多肋横截面形状的生成模型.
- 建立一个适合形状分布的框架,并将它们与不同肋骨类别的人类学联系起来.
- 为了使生物医学和生物机械研究的各种肋骨形状的生成.
主要方法:
- 从CT图像中的3193条肋骨中提取肋骨横截面形状数据,使用解剖索引系统和正规网格.
- 使用有条件变异自编码器 (CVAE) 与CNN架构,以基于节点坐标和皮层骨厚度建模形状分布.
- 采用辅助分类器来解肋间和肋骨内变化和随机森林回归器来将形状变化与受试者人体测量 (年龄,身高,体重) 联系起来.
主要成果:
- 开发了一种CVAE,能够为指定的类 (性别,肋骨号码2-11) 生成有效的肋骨截面形状.
- 根据人口百分比或特定的人类测量数据 (年龄,身高,体重) 生成形状的能力.
- 成功解了肋骨间和肋骨内变异,将肋骨内变异与高斯分布相匹配.
结论:
- 拟议的管道有效地产生了多样化和现实的肋骨截面形状.
- 生成模型可以通过肋骨类标签和人体测量数据来控制,从而实现个性化的人体模型.
- 这项工作为未来的生物力学研究提供了基础,这些研究可以解释人口层面的肋骨形状变化.
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