调节身体的炎症反应的身体-大脑电路
Hao Jin1,2,3,4, Mengtong Li5,6,7, Eric Jeong5,6,7
1Zuckerman Mind Brain Behavior Institute, Howard Hughes Medical Institute, Columbia University, New York, NY, USA. hao.jin@NIH.gov.
Nature
|May 1, 2024
概括
身体-大脑轴通过神经元将外周炎症连接到大脑来调节免疫反应. 激活这种神经免疫电路使大脑能够控制和抑制有害的炎症反应.
科学领域:
- 神经免疫学
- 生理学
背景情况:
- 身体-大脑轴是包括新陈代谢和营养状态在内的生理过程的关键调节器.
- 新出现的证据强调它在感知和控制器官功能中的作用.
研究的目的:
- 研究身体-大脑轴在调节对外围攻击的免疫反应中的作用.
- 确定脑介导免疫调节的神经回路和机制.
主要方法:
- 单细胞RNA测序以确定神经免疫轴的组成部分.
- 在免疫反应期间观察神经活动的功能成像.
- 基因操纵使特定的神经回路保持沉默或激活.
主要成果:
- 周围的免疫攻击激活了身体-大脑轴,通过神经元向大脑发出信号.
- 大脑积极调节周围的炎症和抗炎症反应.
- 这种电路的遗传沉默导致不受控制的炎症; 激活使神经控制.
结论:
- 身体与大脑的轴心对于调节免疫反应至关重要.
- 针对这种神经免疫电路为炎症和自身免疫性疾病提供治疗潜力.
- 由大脑引起的免疫反应调节可以抑制炎症并促进抗炎状态.
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