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Updated: Jul 7, 2026

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine
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预测抗咳药物的新精神活性物质活性,并评估它们对鱼类的生态毒性

Wen-Jun Shi1, Xiao-Bing Long1, Lei Xin1

  • 1SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China.

The Science of the total environment
|May 1, 2024
PubMed
概括

抗咳药可能具有新的精神活性物质 (NPS) 活性,并对鱼类构成生态风险. 机器学习模型确定了15种抗咳药物,具有潜在的NPS活性和对水生生物的显著毒性.

关键词:
这是一种抗咳药.鱼类 鱼类 鱼类 鱼类 鱼类机器学习 机器学习新的精神活性物质的活性.毒性评估 毒性评估 毒性评估

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...