相关实验视频
Updated: Jun 27, 2025

09:17
Point-of-Care Lung Ultrasound in Adults: Image Acquisition
Published on: March 3, 2023
6.0K
曲力和多叶膜上皮细胞之间的波形折叠
Joseph Sutlive1, Betty S Liu1, Stacey A Kwan1
1Laboratory of Adaptive and Regenerative Biology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Bio Systems
|May 1, 2024
概括
膜上皮细胞中的波纹折叠是由肺扩张过程中细胞周长,而不是表面积过多引起的. 这种细胞曲适应了内脏器官扩张和组织力量.
科学领域:
- 生物物理学的生物物理.
- 细胞生物学 细胞生物学
- 人体解剖学 解剖学 解剖学
背景情况:
- 细胞形状和几何学受到组织内的生物物理力的影响.
- 组织力量可以改变细胞特征,如表面积和几何形状.
- 斑膜上皮细胞在不同肺体积处表现出波状.
研究的目的:
- 为了研究在多叶上皮细胞中波形折叠背后的生物物理机制.
- 为了确定是否增加细胞表面积或周边驱动折叠形成.
- 了解肺体积的变化如何影响多细胞形态.
主要方法:
- 检查了不同肺体积的多叶上皮细胞的二维形状,大小和周长.
- 根据达尔西·普森的原则开发了一个物理模拟器.
- 创建了一个数值模拟,以模拟不同细胞尺寸的细胞-细胞接口变化.
主要成果:
- 胸膜上皮细胞的二维表面积增加了1.53倍,周围面积增加了1.43倍,肺部总容量与肺部残留体积相比.
- 物理和数值模拟表明,细胞周长的增加,而不是表面积,直接影响波形折叠的形成.
- 波状折叠在整个肺体积中是一致的,这表明有一个持续的适应机制.
结论:
- 膜上皮细胞中的波纹折叠是由于细胞周长过大而导致的曲力造成的.
- 这种细胞适应对于适应内脏器官扩张至关重要.
- 这些发现强调了细胞周围在器官体积变化期间组织力学中细胞周围的作用.
相关概念视频
Pleura of the Lungs
1.8K
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
1.8K
Pressure Relationships in Thoracic Cavity
2.3K
Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
2.3K
Pleural Effusion I: Introduction
933
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
933
Pleural Disorders: Types and Brief Description
203
The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
203
Factors Affecting Pulmonary Ventilation
1.3K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.3K
Pulmonary Cycle: Exhalation
1.6K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.6K

