在炎症性关节炎的老年患者中,发放风湿药物的性别相关差异:基于人口的研究
Sanjana Tarannum1, Jessica Widdifield2, C Fangyun Wu3
1S. Tarannum, MBBS, MSc, Department of Medicine, Bangladesh Specialized Hospital Ltd, Dhaka, Bangladesh.
The Journal of rheumatology
|May 1, 2024
概括
年长的女性类风湿性关节炎患者接受了更多的阿片类药物和NSAIDs,但DMARD使用没有显示性别差异. 需要进一步的研究,以了解RA和PsA的药物治疗中的这些差异.
科学领域:
- 类风湿病学 类风湿病学
- 老年医学 老年医学
- 药学流行病学 药学流行病学
背景情况:
- 对类风湿性疾病的药物使用的性别差异尚不清楚.
- 患有早期类风湿性关节炎 (RA) 和牛皮性关节炎 (PsA) 的老年人 (≥66岁) 是一个脆弱的人群.
- 了解药物模式对于优化治疗和解决潜在差异至关重要.
研究的目的:
- 为了比较年长的男性和女性患者之间诊断出早期的RA和PSA的各种类风湿药物的处方.
- 为了确定疾病修饰性抗风湿药物 (DMARDs),NSAIDs,阿片类药物和口服皮质类固醇的使用中潜在的基于性别的差异.
主要方法:
- 使用加拿大安大略省 (2010-2017) 的卫生行政数据进行的回顾性队列研究.
- 包括66岁以上的患有发生性RA和PSA的患者.
- 多变量回归模型被用来比较每年药物开放超过3年后的诊断,调整混因素.
主要成果:
- 分析包括13,613名RA患者 (64%女性) 和1116名PsA患者 (57%女性).
- 女性RA患者接受阿片类药物 (OR 1.39-1.51) 和NSAID (OR 1.14-1.16) 的可能性更高.
- 对于RA或PsA,在DMARD处方中没有观察到显著的性别差异.
结论:
- 在使用DMARDs治疗老年RA和PsA患者时,没有发现基于性别的差异.
- 在女性RA患者中,阿片类药物和NSAIDs的使用率更高,需要进一步调查.
- 一致的患者和医生性别与在RA中更强烈地使用先进的DMARD和在PsA中使用csDMARD有关.
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