Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Why do I use generative artificial intelligence (GenAI) to seek health information? A perceptual perspective of GenAI users.

Frontiers in public health·2026
Same author

Contrast enhanced ultrasound at first month: A feasible predictor for retreatment after benign thyroid nodule thermal ablation.

European journal of radiology·2026
Same author

Synergistic removal of lead and zinc ions from the wastewater by cross-linked carbamate starch-g-triethylenetetramine in the presence of sodium butyl xanthate.

International journal of biological macromolecules·2025
Same author

Noninvasive prediction of high-risk esophageal varices by spleen and liver stiffness measurements using sound touch elastography.

Liver research (Beijing, China)·2025
Same author

Deep learning radiomics of elastography for diagnosing compensated advanced chronic liver disease: an international multicenter study.

Visual computing for industry, biomedicine, and art·2025
Same author

Dynamic changes in liver stiffness measurement by 2D shear-wave elastography predict hepatocellular carcinoma in patients with chronic hepatitis B and well-controlled viremia: a retrospective study.

BMC gastroenterology·2025

相关实验视频

Updated: Jun 27, 2025

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection
09:30

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection

Published on: August 15, 2011

43.0K

在电极-组织接口上进行空间精确的基因工程.

Ke Xu1,2,3, Yinan Yang1,2,3, Jianfei Ding1

  • 1CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.

Advanced materials (Deerfield Beach, Fla.)
|May 1, 2024
PubMed
概括

这项研究将灵活的神经电极与基因沉默RNA相结合,以精确设计电极-组织接口. 这种方法可以对神经组织进行精确的基因改造,以改善大脑机器接口.

关键词:
电极 - 组织接口接口这种基因被淘汰了.基因工程是基因工程,是基因工程.神经接口的神经接口

更多相关视频

High efficiency, Site-specific Transfection of Adherent Cells with siRNA Using Microelectrode Arrays MEA
09:14

High efficiency, Site-specific Transfection of Adherent Cells with siRNA Using Microelectrode Arrays MEA

Published on: September 13, 2012

13.5K
Methods for Precisely Localized Transfer of Cells or DNA into Early Postimplantation Mouse Embryos
09:04

Methods for Precisely Localized Transfer of Cells or DNA into Early Postimplantation Mouse Embryos

Published on: December 25, 2015

10.4K

相关实验视频

Last Updated: Jun 27, 2025

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection
09:30

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection

Published on: August 15, 2011

43.0K
High efficiency, Site-specific Transfection of Adherent Cells with siRNA Using Microelectrode Arrays MEA
09:14

High efficiency, Site-specific Transfection of Adherent Cells with siRNA Using Microelectrode Arrays MEA

Published on: September 13, 2012

13.5K
Methods for Precisely Localized Transfer of Cells or DNA into Early Postimplantation Mouse Embryos
09:04

Methods for Precisely Localized Transfer of Cells or DNA into Early Postimplantation Mouse Embryos

Published on: December 25, 2015

10.4K

科学领域:

  • 神经科学是一个神经科学.
  • 生物材料工程 生物材料工程
  • 基因工程是一种基因工程.

背景情况:

  • 电极 - 组织接口对于神经记录和调制至关重要.
  • 目前的研究重点是非生物材料和神经电极的结构工程.
  • 整合生物工程原理为增强这种接口提供了一种新的方法.

研究的目的:

  • 开发一种多功能系统,用于基因工程的电极-组织接口.
  • 为了研究特定基因敲除在接口上的神经组织的影响.
  • 为了实现对神经组织属性的精确控制,用于先进的大脑机器接口.

主要方法:

  • 超灵活的神经电极与短毛针RNAs (shRNAs) 结合.
  • 微型RNA被设计用于沉默内源基因,特别是10号染色体上被删除的酸酶和张素同类基因 (PTEN) 和聚皮里米丁通路结合蛋白1 (PTBP1).
  • 该系统在帕金森病和创伤性脑损伤的小鼠模型中进行了测试,以长期监测神经活动.

主要成果:

  • 在电极接口处的神经组织中实现了shRNA介导的PTEN和PTBP1的淘汰.
  • 证明PTEN下调导致神经元细胞体扩大.
  • 能够在疾病模型中长期监测基因淘汰后的神经活动.

结论:

  • 这种综合的非生物和生物方法为电极-组织接口提供了精确的基因工程.
  • 该系统有助于精确控制神经组织特性,提高电极性能.
  • 为再生电子和下一代大脑机器接口铺平了道路.