COVID-19 病理学 肺部疾病 肺部疾病
1Department of Pathology, Northwell Health, 2200 Northern Boulevard Suite 104, Greenvale, NY 11548, USA.
Surgical pathology clinics
|May 1, 2024
概括
严重的COVID-19肺损伤涉及来自病毒感染,免疫反应和二次感染的扩散性气膜损伤. 需要进一步的研究,以了解在最初的疾病后持续的肺功能障碍.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 严重的COVID-19肺损伤的特征是扩散的气膜损伤.
- 其他观察到的模式包括急性纤维组织性肺炎,组织性肺炎和支气管炎.
- 病原发生涉及病毒损伤,免疫失调和二次感染.
研究的目的:
- 在严重的COVID-19幸存者中阐明持续性肺功能障碍的潜在机制.
主要方法:
- 从重症COVID-19患者的肺组织的组织病理学检查.
- 分析病因因素,包括病毒载量,免疫标记物和微生物培养物.
主要成果:
- 扩散膜损伤是严重的COVID-19肺损伤的主要发现.
- 导致的因素包括主要的病毒侮辱,过度的免疫反应和细菌/真菌超级感染.
- 尽管死亡率有所降低,但仍然存在显著的肺部继发症.
结论:
- 了解导致肺损伤的因素的复杂相互作用至关重要.
- 进一步调查持续性肺功能障碍的发病原因是有必要的,以改善患者的治疗结果.
相关概念视频
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
Pneumonia II: Pathophysiology
261
The pathophysiology of pneumonia involves the following steps:
261
COPD: Pathogenesis and Clinical Features
265
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
265
Pulmonary Tuberculosis II
226
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
226
Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Cystic Fibrosis: Pathogenesis
224
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
224


