冠状动脉化进展与替代疗法的衰竭发展之间的关联:KNOW-CKD研究的发现
Cheol Ho Park1, Hyung Woo Kim1, Jung Tak Park1
1Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Atherosclerosis
|May 1, 2024
概括
冠状动脉化 (CAC) 的进展显著增加了慢性病 (CKD) 患者的替代疗法 (KFRT) 衰竭的风险. 监测CAC变化可能有助于预测CKD进展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 高度的冠状动脉化 (CAC) 负担是心血管和病的已知危险因素.
- 冠状动脉样硬化和病进展之间的关系尚不清楚.
研究的目的:
- 评估冠状动脉化 (CAC) 的进展与慢性病 (CKD) 患者在替代疗法 (KFRT) 中衰竭的风险之间的关联.
主要方法:
- 对1173名患有慢性脏病 (G1-G5) 的参与者的分析,来自韩国对慢性脏病患者 (KNOW-CKD) 结局的队列研究.
- 参与者根据CAC得分在4年中的变化进行分组:非进展者 (≤0AU),中度进展者 (1-199AU) 和严重进展者 (≥200AU).
- 主要结局是KFRT的发病率,评估时间为4.2年的中位随访期.
主要成果:
- 与非进展者相比,KFRT的发病率在中度 (54.3人/1000人/年) 和严重 (80.9人/1000人/年) 的进展者中较高 (37.6人/1000人/年).
- 多变量分析显示,在中度 (HR 1.71) 和严重的进展者 (HR 2.55) 与非进展者之间,KFRT的危险比率显著增加.
- 使用100AU的CAC进展值的灵敏度分析产生了类似的结果.
结论:
- 冠状动脉化的进展独立地与CKD患者的替代疗法增加功能衰竭的风险有关.
- 冠状动脉样硬化负担的变化可能会导致病的进展.
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