心声图和多平面门采集扫描的比较,用于预测与癌症治疗有关的心血管功能障碍
Mark T Nolan1, Faraz Pathan2, Louise Nott3
1Baker Heart and Diabetes Institute, Melbourne, Vic, Australia.
Heart, lung & circulation
|May 1, 2024
概括
对癌症治疗相关心脏功能障碍 (CTRCD) 的检测,心声谱比MUGA更为敏感. 这些心脏成像方法之间存在显著的差异,可能导致误诊.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 目前的指导方针建议进行顺序心脏成像,以监测与癌症治疗有关的心脏功能障碍 (CTRCD).
- 存在多种心脏成像模式,但比较研究有限.
- 这项研究解决了对现实世界数据的需求,比较不同的成像策略.
研究的目的:
- 为了比较多重收购核心室内膜学 (MUGA) 与用于检测CTRCD的新回声心脏学策略.
- 为了评估MUGA和心声回声扫描左心室喷射率 (LVEF) 测量之间的一致性.
- 评估全球纵向应变在预测心脏功能障碍方面的准确性.
主要方法:
- 一项前性队列研究,涉及35名接受心脏毒性化疗 (环素和/或特拉斯图祖马布) 的患者.
- 同时的MUGA和心声成像在指南推的时间点进行.
- 结果包括遵守指南,LVEF测量一致性和CTRCD检测 (定义为>5%的LVEF下降).
主要成果:
- 测量MUGA和回声心脏学LVEF的相关性很差 (达成一致的界限为30-37%).
- MUGA诊断出2.9%的CTRCD,而心声回声检测出34.2%.
- 在2个月的全球纵向菌株预测了CTRCD,AUC为0.75.
结论:
- 在CTRCD诊断中,MUGA和心声回声学之间存在显著的差异.
- 对检测CTRCD而言,心声成像似乎比MUGA更敏感.
- 建议每位患者使用单个成像模式,以防止由于模式间变化的误诊.
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