长非编码RNALOXL1-AS1:在人类恶性瘤中是一种潜在的生物标志物和治疗标
Xiao-Ping Fu1, Chun-Yan Ji2, Wen-Qian Tang1
1Department of Health Management Center, Hubei Provincial Hospital of Traditional Chinese Medicine, Hongshan District, 856 Luoyu Road, Wuhan, 430070, People's Republic of China.
Clinical and experimental medicine
|May 1, 2024
概括
长非编码RNA LOXL1-AS1通过调节细胞过程和信号通路,在各种人类癌症中发挥关键作用. 这种IncRNA显示出作为癌症生物标志物和治疗点的前景.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 长非编码RNAs (lncRNAs) 是人类癌症的关键调节者,尽管它们不编码蛋白质.
- 像1反感性RNA 1 (LOXL1-AS1) 这样的lysyl氧化酶是一种新发现的lncRNA,涉及多种癌症类型.
研究的目的:
- 审查LOXL1-AS1在人类恶性瘤中的生物功能和临床意义.
- 探索LOXL1-AS1作为癌症生物标志物和治疗点的潜力.
主要方法:
- 对研究LOXL1-AS1在各种癌症中的研究进行文献综述.
- 分析LOXL1-AS1的机制,包括其作为竞争的内源RNA (ceRNA) 菌miRNAs的作用.
- 检查LOXL1-AS1在与癌症相关的信号通路 (例如PI3K/AKT,MAPK) 和细胞过程中的参与.
主要成果:
- 在许多癌症中,LOXL1-AS1的调节失调,包括结肠直肠,胃,肝脏,前列腺,肺,卵巢,宫,乳腺,质瘤,胸腺和胰腺癌.
- 洛克斯L1-AS1通过海绵化各种微RNAs (miRNAs) 来促进瘤的进展,影响细胞增殖,入侵,迁移,细胞亡,细胞循环和上皮-介质细胞过渡 (EMT).
- LOXL1-AS1影响关键的癌症信号通路,如PI3K/AKT和MAPK.
结论:
- LOXL1-AS1在各种人类癌症的发展和进展中发挥着重要作用.
- LOXL1-AS1的多方面的作用表明它作为可靠的诊断生物标志物和癌症治疗的有希望的治疗标的潜力.
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