在中度和高度肺神经内分泌瘤中,新型免疫疗法点的表达模式
Bence Ferencz1,2, Klára Török1,2, Orsolya Pipek3
1Department of Thoracic Surgery, Semmelweis University and National Institute of Oncology, Budapest, Hungary.
Cancer immunology, immunotherapy : CII
|May 1, 2024
概括
肺部神经内分泌瘤 (LNENs) 显示出不同的免疫疗法点模式,如VISTA,OX40L,GITR和TIM3. 了解这些差异对于开发针对LNENs的新免疫疗法至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 翻译研究是翻译研究.
背景情况:
- 免疫疗法在治疗肺部神经内分泌瘤 (LNENs) 中表现出有限的成功.
- 新型免疫疗法目标需要在中级和高级LNEN中进行研究.
研究的目的:
- 调查LNEN亚型中V域Ig抑制T细胞激活 (VISTA),OX40L,葡萄糖皮质醇诱导的TNF受体 (GITR) 和T细胞免疫球蛋白和粘素域3 (TIM3) 的表达模式.
- 为了比较这些表达模式跨非典型的癌 (AC),大细胞神经内分泌肺癌 (LCNEC) 和小细胞肺癌 (SCLC).
主要方法:
- 免疫组织化学用于测量VISTA,OX40L,GITR和TIM3蛋白质的表达.
- 分析了来自26名AC,49名LCNEC和66名SCLC患者的瘤样本.
- 对瘤和免疫细胞的表达水平分别得分.
主要成果:
- 瘤细胞TIM3和GITR表达分别在AC和SCLC中最高.
- 与SCLC相比,OX40L表达在AC中较低,而VISTA表达在所有亚型中较低.
- 与SCLCs和LCNECs相比,ACs表现出较低的免疫细胞丰度和较低的免疫细胞VISTA和GITR表达.
结论:
- 在LNEN亚型中存在VISTA,OX40L,GITR和TIM3的明显和不同的表达模式.
- 这些发现为针对不同LNEN量身定制新型免疫治疗策略提供了基础.
- 了解这些目标表达式可能会改善LNEN患者未来的治疗结果.
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