设计基于目标空间分析的组合草药
Assefa Mussa Woyessa1,2, Lemessa Etana Bultum2,3, Doheon Lee4,5
1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
BMC complementary medicine and therapies
|May 1, 2024
概括
传统东方医学 (TOM) 配方显示了与治疗相同疾病的药物药物有显著的目标重叠. 这项研究验证了TOM的疗效,并提供了关于管理传统治疗副作用的见解.
科学领域:
- 药理学 药理学是指药理学的学科.
- 计算生物学 计算生物学
- 综合医学是一个整体医学.
背景情况:
- 传统东方医学 (TOMs) 与传统药物相比,提供了替代的治疗哲学.
- 这项研究将TOM配方与制药药物数据相结合,用于比较目标空间分析.
- 对焦虑,糖尿病,,高血压,肥胖和精神分裂症的46种TOM配方进行了策划.
研究的目的:
- 提供TOM配方在治疗主要适应症中的有效性的科学证据.
- 分析TOM配方和小分子药物之间的目标空间重叠.
- 评估TOMs在管理与制药药物相关的副作用方面的潜力.
主要方法:
- 46种TOM配方和相关疾病治疗的手工制.
- 吸收,分布,新陈代谢,分泌和毒性 (ADMET) 属性分析以过有毒的草本成分.
- 目标空间分析比较TOM配方和小分子药物,用于相同和不同的疾病治疗.
- 使用支持值和随机目标空间分布进行统计验证.
- 使用Si-Wu-Tang (SWT) 公式和现有文献进行评估.
主要成果:
- 在TOM配方和治疗相同疾病的小分子药物之间观察到显著的目标空间重叠 (例如:支持值0.84).
- 与随机选择的目标空间相比,重叠的目标数量在同一种疾病的治疗中要高得多.
- 科学文献支持分析的TOM配方中的单个草药的药用功效.
结论:
- 目标空间分析提供了TOM配方在治疗初级症状中的有效性的证据.
- 这种方法证明了TOMs在解决与药物药物使用相关的副作用方面的潜力.
- 该研究支持将TOM和制药药物整合到综合性患者护理中.
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