从论文到基于RDF的物理化学数据的整合以及纳米材料的不良结果途径
Jeaphianne P M van Rijn1, Marvin Martens1, Ammar Ammar1
1Dept of Bioinformatics, BiGCaT, NUTRIM, FHML, Maastricht University, Maastricht, The Netherlands.
Journal of cheminformatics
|May 1, 2024
概括
本研究引入了一个数据库,将工程纳米材料 (ENM) 与它们的分子启动事件 (MIE) 联系起来. 这有助于理解ENM与生物系统的相互作用,并支持纳米信息学和纳米安全研究.
科学领域:
- 纳米材料科学科学 纳米材料科学
- 毒理学 毒理学 毒理学
- 生物信息学是一种生物信息学.
背景情况:
- 负面结果途径 (AOPs) 有助于理解化学生物相互作用.
- 关于工程纳米材料 (ENM) 特定的AOP信息是有限的.
- 生物系统与ENM的相互作用需要进一步阐明.
研究的目的:
- 整合关于ENM及其分子启动事件 (MIE) 的现有数据.
- 开发一种用于查询与ENM相关的AOP和生物通路的方法.
- 加强纳米信息学和纳米安全知识整合.
主要方法:
- 使用本体学对ENM及其MIE的注释.
- 集成收集的数据和知识.
- 语义网络技术的应用.
主要成果:
- 一个新的数据库将ENM压力因素与其MIE或关键事件 (KE) 联系起来.
- 一个可重复的工作流程,用于分析和总结ENM-MIE知识.
- 对ENMs查询AOP和生物途径的演示.
结论:
- 对ENM-MIE知识的公平数据表示简化了整合.
- 这项工作通过语义网络技术推进纳米信息学和纳米安全.
- 开发的方法有助于理解ENM的生物相互作用.
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