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治疗炎症性肠病的益生菌;深入研究它们对疾病过程及其相关健康风险的影响
Wassan Nori Mohammed Hassan1, Methaq Mueen Al-Kaabi2, Nabeeha Najatee Akram3
1Department of Obstetrics and Gynecology, Mustansiriyah University, Baghdad, Iraq.
Current medicinal chemistry
|May 2, 2024
概括
益生菌在治疗炎症性肠病 (IBD),特别是性结肠炎方面表现有前途,通过改善缓解和降低相关风险. 需要进一步的研究来确定它们对克罗恩病的疗效.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 的确切病理仍然不清楚.
- 肠道微生物群失生症越来越多地与IBD的发展和进展有关.
- 益生菌正在研究其恢复肠道健康和管理IBD的潜力.
研究的目的:
- 审查有关益生菌对IBD成年患者的益处的现有文献.
- 检查益生菌在性结肠炎 (UC) 和克罗恩病 (CD) 的疗效和安全性.
- 评估益生菌对IBD相关并发症和并发症的影响.
主要方法:
- 对相关研究进行了对多个数据库的全面搜索.
- 在成年IBD患者中检查益生菌的符合条件的研究被选择和分析.
- 审查的重点是益生菌菌株,作用机制和临床结果.
主要成果:
- 益生菌在减少疾病活性,诱导和维持性结肠炎患者的缓解方面表现出有效性.
- 支持在克罗恩病中使用益生菌的证据有限.
- 益生菌对IBD相关风险产生了积极的影响,包括胃肠道恶性瘤,生育能力,骨质疏松症,心血管事件和心理健康.
结论:
- 益生菌被推作为性结肠炎的辅助疗法.
- 需要进一步的研究来确定益生菌在克罗恩病管理中的作用和最佳使用.
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