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对抗细胞内细菌感染的协同抗生素/ROS/NO/免疫疗法的级联向纳米平台

Xiaomei Dai¹, Xiaojun Liu¹, Xingxing Wang¹

¹Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, P. R. China.

Biomacromolecules

|May 2, 2024

概括

这项研究开发了新的纳米平台,通过将向药物输送与协同疗法结合起来,以对抗持续的细胞内细菌感染,包括反应性氧物种 (ROS) 和氧化 (NO) 生成,以增强抗菌作用.

科学领域:

纳米医学是一种纳米医学.
传染性疾病传染性疾病
免疫治疗是一种免疫疗法.

背景情况:

休眠状态中的细胞内细菌由于免疫逃避和抗生素耐受性而带来重大挑战,导致持续性感染.
目前的治疗方法往往难以消除细胞内细菌储存库,需要创新的治疗策略.

研究的目的:

开发和评估一种新型的级向纳米平台,以加强细胞内细菌感染的根除.
调查抗生素输送,活性氧物种 (ROS),氧化 (NO) 生产和免疫疗法的协同效应.

主要方法:

制造脂胺 (PS) 涂层纳米颗粒 (PTVPs) 封装三糖 (Tr) 和胺 (Van).
PTVP被设计为双重向:通过PS初始的巨吸收和随后的细胞内细菌向.
纳米颗粒被设计为在对细胞内谷氨 (GSH) 和酸性环境的反应中释放Van,从l-arginine (Arg) 产生NO,并通过N,N egular-bisacryloylcystamine (BAC) 诱导ROS.

主要成果:

该纳米平台展示了有效的巨细胞向和细胞内细菌向.
观察到万科米辛的受控释放,氧化 (NO) 和活性氧物种 (ROS) 的产生,以及诱导促炎反应.
联合治疗作用导致加强了对细胞内细菌的抗菌能力.

结论:

开发的纳米平台为治疗细胞内细菌感染提供了一个有希望的新策略.
协同向,药物输送和多模式治疗措施 (抗生素,ROS,NO,免疫疗法) 是消除持久性感染的关键.

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