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治疗性深层体系统 (THEDES) 的制药应用,最大限度地提高药物输送效率
Shamama Javed1, Bharti Mangla2, Muhammad H Sultan1
1Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia.
Heliyon
|May 2, 2024
概括
治疗性深层欧特克系统 (THEDES) 为提高药物溶解性和生物可用性提供了一个有前途的解决方案. 这些系统利用绿色溶剂 (DES) 改善药物输送和治疗各种疾病.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 绿色化学 绿色化学
背景情况:
- 活性药物成分 (API) 的溶解性差是药物开发中的一个重大挑战.
- 新型药物输送系统对于提高药物疗效和生物可用性至关重要.
- 治疗性深层欧特克系统 (THEDES) 代表了一种创新的方法来克服可溶性问题.
研究的目的:
- 审查THEDES的成分,配方策略和使用途径.
- 突出THEDES在药物溶解和输送中的制药应用.
- 讨论THEDES在治疗代谢和非代谢疾病方面的潜力.
主要方法:
- 通过将API与深度性溶剂 (DESs) 混合THEDES的配方.
- 对于溶解性和透性增强的THEDES的表征.
- 审查关于THEDES在药物输送和疾病管理中的应用现有文献.
主要成果:
- 在提高难以溶解药物的可溶性和透性方面,THEDES具有显著的潜力.
- 深度浸泡溶剂 (DES) 是无毒的,具有成本效益,可生物降解,易于制备.
- 对于各种药物输送途径和治疗应用,THEDES显示出前景.
结论:
- THEDES是一种可行的,有利的药物输送系统,可以提高API的溶解性和生物可用性.
- 在THEDES中使用DES等绿色溶剂符合可持续的制药实践.
- 对THEDES的进一步研究为推进制药配方和疾病治疗提供了重大潜力.
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