细胞因子风暴在呼吸系统疾病中的关键影响
Shahana Riyaz Tramboo1, Ahmed M E Elkhalifa2,3, Syed Quibtiya4
1Preclinical Research Laboratory, Department of Clinical Veterinary Medicine, Ethics & Jurisprudence, Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST-Kashmir), Srinagar, J&K, 190006, India.
Heliyon
|May 2, 2024
概括
细胞因子风暴 (CS) 是一种严重的免疫过度反应,与严重疾病和COVID-19等疾病的不良结果有关. 了解CS病因是开发新疗法和改善患者存活率的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 关键护理医学 关键护理医学
背景情况:
- 细胞因子风暴 (CS) 是一种超炎症反应,与严重感染和器官衰竭有关.
- 导致COVID-19的新型冠状病毒 (SARS-CoV-2) 与重症患者的CS有关,导致严重的预后.
- CS的特点是免疫过度活化和多器官衰竭的临床表现.
研究的目的:
- 讨论细胞因子风暴的病因,后果和管理.
- 探索COVID-19和其他呼吸道疾病中CS的潜在治疗方法和生物标志物.
- 从预防和治疗的角度提供对CS的见解.
主要方法:
- 关于细胞因子风暴的专家意见的审查.
- 临床病例控制研究的分析.
- 包括实验研究和对病例控制的队列研究在呼吸道疾病中对CS进行研究.
主要成果:
- 细胞因子风暴是COVID-19和其他呼吸系统疾病的严重性和死亡率的一个重要因素.
- 了解CS病原体可以识别风险因素和治疗点.
- 最近在呼吸道疾病中对CS的全球研究结果已被编制.
结论:
- 深入了解CS对于开发有效的干预措施至关重要.
- 在CS中调节免疫反应可以改善呼吸道疾病的结果.
- 对CS生物标志物和治疗方法的进一步研究是有必要的,以改善患者管理.
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