在患有慢性疾病的青少年中,大动脉硬度的增强与左心室全球纵向应变的减少有关
Victor A Verpalen1,2, Francesca A Ververs3, Martijn Slieker1
1Department of Pediatric Cardiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, the Netherlands.
概括
患有慢性疾病的青少年表现出大动脉硬度增加,与心脏功能降低 (LVGLS) 有关. 这表明潜在的长期心血管风险需要进一步调查.
科学领域:
- 心血管研究的心血管研究.
- 儿科心脏病学 儿科心脏病学
- 医学成像医学成像
背景情况:
- 患有慢性疾病的青少年表现出较高的主动脉硬度和壁壁厚度.
- 大动脉硬度增加可能导致左心室 (LV) 后负荷增加和不良的动脉脉相互作用.
研究的目的:
- 在慢性疾病青少年心血管疾病 (CDACD) 研究中调查青少年大动脉变化和LV功能之间的关系.
主要方法:
- 在114名青少年 (12-18岁) 患有囊性纤维化,大动脉缩,青少年异常性关节炎,肥胖症和健康对照者的横截面研究.
- 使用心血管磁共振成像 (CMR) 评估大动脉脉冲波速 (PWV) 和大动脉壁厚度 (AWT).
- 通过心声学评估LV功能标志物,包括LV全球纵向菌株 (LVGLS).
主要成果:
- 与对照组相比,所有慢性疾病组都显示出大动脉PWV和AWT的增加.
- 患有主动脉缩,青少年异常性关节炎和肥胖症的青少年显示LVGLS降低,LV维度正常,常规功能标志物正常.
- 多变量回归显示大动脉PWV是减少LVGLS的主要决定因素 (标准化β-0.522,p < 0.001).
结论:
- 患有某些慢性疾病的青少年减少LVGLS与大动脉硬度增加有关,这表明潜在的不良动脉脉相互作用.
- 需要进一步的研究来确定这种减少的LVGLS是否会影响这些患者群体的长期心血管结果.
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