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调查凝血参数与COVID-19感染死亡率之间的关系

Fatih Ikiz¹, Ahmet Ak²

¹Department of Emergency Medicine, Beyhekim Training and Research Hospital, Selcuklu, Konya, Turkey.

Blood science (Baltimore, Md.)

|May 2, 2024

概括

凝血标志物如d-二聚体和纤维素因子与COVID-19患者的死亡率更高有关. 监测这些,以及临床数据,改善预测患者的生存结果.

科学领域:

医学研究医学研究
血液学血液学血液学
传染性疾病传染性疾病

背景情况:

冠状病毒疾病2019 (COVID-19) 带来了显著的死亡风险.
在严重的COVID-19病例中经常观察到凝血异常.
了解死亡率预测因素对于患者管理至关重要.

研究的目的:

调查COVID-19患者的特定凝血参数和死亡率之间的关联.
评估凝血标记物对COVID-19结果的预测价值.

主要方法:

对成人COVID-19患者进入急诊室的回顾性分析.
评估人口,临床,生命和凝血参数 (d-二聚体,PT,aPTT,INR,纤维素,血小板).
统计分析包括接收器操作特征 (ROC) 和回归模型.

主要成果:

在老年患者中观察到升高的d-二聚体,纤维素,INR和PT.
较高的d-二聚合物水平与更长的住院时间相关.
增加的d-二聚和纤维素素,以及降低血小板和aPTT,与增加的死亡率有关.
在ROC分析中,d-二聚合物和纤维原蛋白具有显著的诊断潜力.

结论:

凝血参数包括d-二聚体,纤维素原,aPTT和血小板计数与COVID-19死亡率有显著的关联.
将凝血标记与临床,重要和人口统计数据相结合,可以提高死亡率预测的准确性.

关键词:

在 COVID-19 疫情中,凝血是凝固的过程.实验室参数实验室参数死亡率死亡率死亡率预测预后预测预测

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