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从非线性和调解的角度研究出生体重和乳腺癌之间的关系
Meng Zhang1, Jiahao Qiao1, Ping Zeng1,2,3,4,5
1Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Iranian journal of public health
|May 2, 2024
概括
出生的体重通过初潮和更年期的年龄等间接途径影响乳腺癌风险. 发现了一个非线性关联,在绝经前妇女中特别强烈,突出了复杂的出生体重与乳腺癌的联系.
科学领域:
- 生殖流行病学 生殖流行病学
- 在瘤学瘤学.
- 人类遗传学 人类遗传学
背景情况:
- 以前的流行病学研究表明出生体重与乳腺癌风险之间存在联系,但研究结果不一致.
- 这项研究使用英国大型生物银行队列重新检查了出生体重与乳腺癌的关联.
研究的目的:
- 研究出生体重和乳腺癌之间的因果调解,将初潮和更年期的年龄视为调解因素.
- 探索出生体重与乳腺癌风险之间的潜在非线性关系.
- 分析由更年期状态分层的关联.
主要方法:
- 利用英国生物库数据从5,760例乳腺癌病例和162,778对照 (白人英国志愿者,2006-2010).
- 采用传统的调解分析来评估通过初潮和更年期的间接影响.
- 通过包括出生体重和出生体重类别的平方来研究非线性关联.
- 根据更年期状态进行了分层分析.
主要成果:
- 出生体重间接影响成年人乳腺癌的风险通过年龄在初潮和更年期.
- 确定了出生体重和乳腺癌之间的统计学上显著的非线性关联 (β=0.062,P=0.004为出生体重的平方).
- 非线性关联在绝经前妇女中 (27.5%的风险增加) 与绝经后妇女 (19.5%的风险增加) 相比更为明显.
结论:
- 出生体重和乳腺癌之间的关系是由非线性效应和因果调解驱动的.
- 出生体重对乳腺癌风险的影响是复杂的,由生殖因素介导,并表现出非线性模式.
- 研究结果提供了更深入的洞察力,了解早期生活因素与晚期癌症发展之间的细微联系.
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