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在三个差异性选择的Nellore牛群中检测和描述副本数量的变化

Lorena F Benfica^1,2, Luiz F Brito¹, Ricardo D do Bem²

¹Department of Animal Sciences, Purdue University, West Lafayette, IN, United States.

Frontiers in genetics

|May 2, 2024

概括

副本数变异 (CNVs) 揭示了Nellore牛的遗传差异,这些牛为生长和料效率而选择. 这些发现提高了对改善牛肉生产特征的遗传基础的理解.

科学领域:

基因组学就是基因组学.
动物遗传学动物遗传学
量化遗传学量化遗传学

背景情况:

尼罗尔牛 (Bos taurus indicus) 是巴西的一个关键的牛肉品种,经过性能特征的遗传选择.
一个实验性育种计划开发了三个不同的线条:内罗尔控制 (NeC),内罗尔选择 (NeS) 和内罗尔传统 (NeT).
选择重点是年幼体重 (YW) 和剩余料摄入量 (RFI),以改善牛肉生产.

研究的目的:

识别Nellore牛的复制数变异 (CNVs) 在三个选择线上.
在这些行中,描述副本数变异区域 (CNVR).
对已识别的CNVR进行功能丰富分析,以了解它们的生物学意义.

主要方法:

全基因组分析以检测复制数变异 (CNVs).
在染色体中识别和描述拷贝数变异区域 (CNVRs).
对已识别的CNVR进行基因注释和基因本体学 (GO) 丰富分析.

主要成果:

在所有线条中确定了14,914个独特的CNV和1,884个CNVR.
在NeC,NeS和NeT线之间,CNVR分布差异很大,其中NeT线最多.
每个基因系中的独家CNVR与生长和代谢至关重要的基因重叠,例如SMARCD3,SLC15A1和MAPK1.

结论:

在为YW和RFI选择的Nellore线路中,CNV和CNVR存在显著的变化.
专属CNVR的功能分析突出了与生长和料效率相关的特定基因和途径.
这些见解有助于理解推动内罗尔牛类表型分歧的遗传机制.

关键词:

尼罗尔尼罗尔尼罗尔在SNP小组中,小组成员是SNP.牛肉牛牛肉牛牛肉牛副本编号变化副本编号变化基因注释基因注释剩余料摄入量的剩余料摄入量

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Comparing Copy Number Variations and SNPs

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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