为高血压患者的药物疾病相互作用制定实际建议
Kübra Özokcu1,2, Maaike M E Diesveld3, Suzan G H Gipmans4
1Department of Hospital Pharmacy, Meander Medisch Centrum, Amersfoort, Netherlands.
Frontiers in pharmacology
|May 2, 2024
概括
皮质类固醇,达纳和约因可以显著影响高血压患者的血压,导致药物疾病相互作用. 这项研究为高血压管理中更安全的药物使用提供了建议.
科学领域:
- 药理学 药理学是指药理学的学科.
- 心脏病学 心脏病学
- 临床实践 临床实践
背景情况:
- 高血压是心血管疾病 (CVD) 的主要危险因素,是全球死亡的主要原因.
- 有效的血压管理 (<140/90 mmHg) 可以显著降低心血管疾病和全因死亡风险.
- 伴随性疾病及其药物可以通过药物疾病相互作用 (DDSI) 复杂化高血压治疗.
研究的目的:
- 在高血压患者中评估影响血压的药物的安全性.
- 为医疗保健专业人员制定关于高血压中DDSI的实际建议.
- 为了确定导致高血压与临床相关药物疾病相互作用的特定药物.
主要方法:
- 采用了六步计划,结合文献审查和多学科专家共识.
- 定义的临床相关的血压变化为>=10 mmHg静缩和>=5 mmHg静缩.
- 对临床相关的高血压DDSI药物进行评估,考虑官方产品信息和临床指南.
主要成果:
- 皮质类固醇,达纳和约因被确定为导致高血压的临床相关DDSI.
- 其他带有高血压警告的药物由于轻微的副作用或数据不足,没有显示出临床相关的DDSI.
- 已知有血压影响的药物,在密切监测下管理,被认为对信号不具有临床意义.
结论:
- 对高血压DDSI的具体建议可以在临床实践中实施,例如在决策支持系统中.
- 在高血压患者中可以实现更安全的药物使用,减少警觉疲劳和改善医疗保健.
- 未来的研究应该评估实施策略及其对减少不安全药物使用的影响.
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