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Updated: Jun 27, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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通过理性结合口袋工程来增强3 - 基基甲基酸酶Tfu_0875的活性和基尼-CoA特异性

Lixia Liu1,2, Shuang Liu1,2, Xiangyang Hu1,2

  • 1National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu, 214122, China.

Synthetic and systems biotechnology
|May 2, 2024
PubMed
概括

改造的3 - 基-CoA硫酶Tfu_0875显示了对基尼-CoA的增强活性和特异性,促进了酸的产生. 计算蛋白质工程策略改善了生物基化学合成的酶性能.

关键词:
3 - 基基-CoA 硫酸盐酸盐.亚酸是亚酸的一种.克莱森的冷凝液是因为 Claisen 的冷凝液.深度学习是一种深度学习.在 GRAPE 战略中,GRAPE 战略包括:

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