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双极性II型抑郁症患者的转换率低于双极性I型抑郁症患者的转换率,这些患者被辅助治疗了第二代抗抑郁药
Lori L Altshuler1, Trisha Suppes1, David O Black1
1From the Department of Psychiatry and Biobehavioral Sciences and Department of Biostatistics, School of Public Health, University of California, Los Angeles; Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; Department of Psychiatry, University Medical Center Groningen, the Netherlands; Biological Psychiatry Branch, NIMH, NIH, Bethesda, Md.; Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Mental Health Care Line and General Clinical Research Center, and Cincinnati VA Medical Center, Cincinnati; Altrech Institute for Mental Health Care, Utrecht, the Netherlands; and Department of Psychiatry, Ludwig-Maxmilians-Universitat Munich.
患有双相II型精神障碍的患者在与患有双相I型精神障碍的患者相比,在接受抗抑郁药与情绪稳定剂一起治疗时,经历了较少的转变为低躁狂或躁狂.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 双极性抑郁症的治疗往往涉及抗抑郁药物,但有诱导躁狂或低躁狂的风险.
- 了解双相I和双相II之间的抗抑郁药诱导情绪切换的差异脆弱性对于安全的治疗至关重要.
研究的目的:
- 为了比较双相I型情绪障碍和双相II型情绪障碍的抑郁患者在接受第二代抗抑郁药治疗时作为情绪稳定剂的辅助剂而转变为低躁狂或躁狂的速度.
主要方法:
- 一项为期10周的临床试验,涉及184名双相抑郁症 (被诊断为双相I,双相II或未确定的双相障碍) 的门诊患者.
- 患者接受了三种抗抑郁药中的一种,作为情绪稳定剂的附加治疗.
- 交换被定义为年轻狂热评分表 (YMRS) 分数>13或临床全球印象 (CGI) 狂热分数≥3.
主要成果:
- 被诊断为患有双相二极性障碍的抑郁患者,急性转变为低躁狂/躁狂的发生率明显较低.
- 这一发现不论是否使用YMRS或CGI标准来定义转换,都是正确的.
结论:
- 与患有双相I型精神障碍的患者相比,患有双相II型精神障碍的抑郁患者似乎对抗抑郁药诱导的情绪转换的脆弱性较小.
- 这些发现支持在双相抑郁症中添加抗抑郁药的处方时采取谨慎的方法,考虑到特定的诊断亚型.
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