Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

3.7K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
3.7K
Microtubules in Signaling01:22

Microtubules in Signaling

1.7K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.7K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

224
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
224
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

157
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
157
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

265
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
265

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Accuracy of Clinical Phenotype for Diagnosing Adults With Primary Ciliary Dyskinesia.

Chest·2026
Same author

Early Life Disease Burden and Outcomes in Children Diagnosed With Primary Ciliary Dyskinesia in Infancy.

Pediatric pulmonology·2026
Same author

Asthma and inhaled corticosteroids in primary ciliary dyskinesia (PCD): a consensus from the Minneapolis PCD meeting.

American journal of respiratory and critical care medicine·2026
Same author

Outpatient assessment of bronchopulmonary dysplasia using point of care lung ultrasound.

Frontiers in pediatrics·2026
Same author

Loss of RPGR disrupts motile cilia and causes primary ciliary dyskinesia by affecting F-actin dynamics.

The Journal of clinical investigation·2026
Same author

Treatment of Lung Disease in Primary Ciliary Dyskinesia: A Review of Current and Emerging Interventions.

Pediatric pulmonology·2026
Same journal

From Screening to Support: Crafting Social Needs Response Systems That Work for Families.

Pediatrics·2026
Same journal

A Social Care Intervention in Pediatric Practices: A Stepped Wedge Cluster Trial.

Pediatrics·2026
Same journal

Pediatric Cheerleading-Related Head Injuries and the "Double Down" Rule Change.

Pediatrics·2026
Same journal

Tobacco Use Among Middle and High School Students: 2025 National Youth Tobacco Survey.

Pediatrics·2026
Same journal

Nirmatrelvir/Ritonavir for the Treatment of COVID-19 in Children Aged 6 Years and Older.

Pediatrics·2026
Same journal

Correction to "Standardized Criteria for Genomic Testing in the NICU".

Pediatrics·2026
查看所有相关文章

相关实验视频

Updated: Jun 27, 2025

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
05:32

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Published on: January 19, 2022

4.3K

主要的状腺失运动症.

Wallace B Wee1,2,3, BreAnna Kinghorn4, Stephanie D Davis5

  • 1Hospital for Sick Children, Toronto, Ontario, Canada.

Pediatrics
|May 2, 2024
PubMed
概括
此摘要是机器生成的。

初级状动力障碍 (PCD) 是一种罕见的遗传疾病,影响状动力,导致慢性呼吸问题. 了解PCD的进展正在改善诊断和管理,但许多病例仍未得到充分承认.

更多相关视频

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

4.8K
Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

12.2K

相关实验视频

Last Updated: Jun 27, 2025

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
05:32

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia

Published on: January 19, 2022

4.3K
Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

4.8K
Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

12.2K

科学领域:

  • 遗传学 是一个遗传学.
  • 肺部病理学 肺部病理学
  • 罕见疾病 罕见疾病

背景情况:

  • 初级状动力障碍 (PCD) 是一种罕见的遗传性疾病,影响状动力的功能.
  • 这种功能障碍导致粘膜干净的受损,导致慢性鼻肺肺疾病和其他严重的健康问题.
  • 尽管研究取得了进展,但PCD在临床实践中经常被诊断不足.

研究的目的:

  • 为了提供一个全面的概述当前对初级状动力障碍 (PCD) 的理解.
  • 突出诊断的最新进展,基因型-表型相关性和PCD的管理策略.
  • 提高临床识别和改善治疗试验的患者鉴定.

主要方法:

  • 本综述综合了当前研究和临床知识的初级状动力障碍 (PCD).
  • 它结合了基因数据库分析和国际合作研究的发现.
  • 该审查侧重于病理生理学,临床表现,诊断实践和治疗方法.

主要成果:

  • 在了解PCD患病率,表型和遗传因素方面取得了重大进展.
  • 新的诊断工具和基因型-表型关联正在出现.
  • 目前的管理策略和创新治疗方法的潜力正在得到完善.

结论:

  • 更好地了解PCD的临床谱和诊断进步可以提高疾病的识别.
  • 加强诊断测试和管理对于受影响的人来说至关重要.
  • 准确的患者鉴定对于注册PCD即将进行的临床治疗试验至关重要.