尿液诺福维尔检测实时PrEP坚持反:一项涉及乌干达跨性别女性的定性研究
Andrew Mujugira1,2, Beyonce Karungi3, Jackson Mugisha1
1The Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Journal of the International AIDS Society
|May 2, 2024
概括
对乌干达的跨性别女性来说,预暴露预防 (PrEP) 的护理点尿液检测是可以接受的,但需要咨询来解决混乱和"白袍剂量"行为. 这种方法可以支持遵守监测和改善艾滋病毒预防策略.
科学领域:
- 实施科学 实施科学
- 艾滋病毒预防研究 预防研究
- 跨性别者健康 跨性别者健康
背景情况:
- 坚持咨询与医疗点 (POC) 药物级别反相结合,可以提高暴露前预防 (PrEP) 坚持.
- 在跨性别女性 (TGW) 中,尿液测试对PrEP遵守的感知和影响尚不清楚.
研究的目的:
- 质量地检查乌干达跨性别妇女的经验,用POC诺福维尔尿液检测.
- 了解对PrEP坚持咨询的看法,包括POC尿液测试的药物级反.
主要方法:
- 一个集群随机试验中的嵌套定性子研究,涉及乌干达30名HIV阴性TGW.
- 采访探讨了POC尿液诺福维尔测试的经验和对坚持咨询的看法.
- 诱导性内容分析用于分析定性数据.
主要成果:
- 最初受到怀疑,POC尿液测试在咨询后被认为是可以接受和有益的.
- 药物级别的反通常与参与者自我报告的坚持一致,加强了对测试准确性的信心.
- 与艾滋病毒自我测试相比,解释尿液检测结果 (两个线表示不遵守) 引起了混乱;护士提供了澄清.
- 一些TGW实行"白色外套剂量",改变临床访问周围的坚持行为,以避免检测不坚持.
结论:
- 将POC尿检整合到PrEP坚持咨询中是可以接受的,对TGW来说可能是有益的.
- 有效实施需要解决上下文因素,包括测试解释和"白袍剂量"的可能性.
- 需要进一步的研究来优化对这一群体的坚持监测和咨询策略.
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