从离散选择实验患者偏好研究中开发慢性阻塞性肺病的疾病特异性健康效用评分
Byron Jones1, Mandy Ryan2, Nigel S Cook3
1Patient Engagement Science, Novartis Pharma AG, Basel, Switzerland.
概括
使用患者偏好开发了慢性阻塞性肺病 (COPD) 的新健康效用评分. 这种疾病特异性测量比通用工具更敏感于COPD的严重程度,并且不像通用工具那样受到伴随性疾病的影响.
科学领域:
- 卫生经济学 卫生经济学
- 患者报告的结果
- 卫生技术评估 卫生技术评估
背景情况:
- 传统的医疗技术评估 (HTA) 依赖于患者的定性投入.
- 越来越需要将患者偏好的定量数据纳入HTA决策中.
- 患者偏好数据可以为特定疾病的健康效用得分提供信息.
研究的目的:
- 为患有慢性阻塞性肺病 (COPD) 的患者生成健康实用评分.
- 在医疗技术评估中评估COPD特定得分的有用性.
- 为了将COPD实用性得分与通用措施和患者感知的严重程度进行比较.
主要方法:
- 定性研究确定了六个主要的COPD症状:呼吸短促,恶化,慢性咳,粘液分泌,睡眠障碍和尿失禁.
- 使用离散选择实验 (DCE) 和随机参数逻辑回归来估计COPD健康状况的效用得分.
- 分析探讨了COPD实用分数,自我感知COPD严重程度和EQ-5D-3L实用分数之间的关系,按疾病严重程度和并发症分层.
主要成果:
- 开发的COPD健康实用性得分证明了面部有效性,得分与自我感知的COPD严重程度相反.
- 在COPD健康效用得分和EQ-5D-3L效用得分之间观察到适度的相关性.
- 与患者EQ-5D-3L得分相比,COPD健康实用性得分受到并发症的影响较小.
结论:
- 由DCE衍生的COPD实用度提供了一个以患者为中心的得分,对个体COPD健康状况敏感.
- 这种特定于疾病的仪器不像通用措施那样受到共同疾病的影响.
- 在HTA提交中,应考虑COPD实用措施与通用生活质量工具一起用于评估新的COPD疗法.
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