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在ST段升高心肌梗塞后间歇性禁食改善左心室功能:随机控制的INTERFAST-MI试验
Jochen Dutzmann1, Zoe Kefalianakis1, Florian Kahles2
1Department of Internal Medicine III (J.D., Z.K., J.-M.D., K.K., D.G.S.), University Hospital Halle (Saale), Germany.
Circulation. Heart failure
|May 2, 2024
概括
间歇性禁食改善了心脏功能,并减少了心血管风险因素在心肌梗塞后的患者. 这种饮食方法被发现是安全的,并且可用于改善STEMI后的心脏健康.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 饮食干预 饮食干预
背景情况:
- 间歇性禁食 (IF) 显示出改善心血管风险因素的前景.
- 在INTERFAST-MI试验中,研究了IF对ST段升高心肌梗塞 (STEMI) 后心脏功能的影响.
研究的目的:
- 评估间歇性禁食对STEMI后心脏功能的影响.
- 评估在后心脏病发作患者中进行更大规模的多中心试验的可行性.
主要方法:
- 一个前性的,随机的,受控的,单中心试验,涉及48名STEMI后的患者.
- 患者被随机分配为间歇性禁食或定期饮食6个月.
- 4周,3个月,6个月后对心脏功能,血压和体重进行了监测.
主要成果:
- 与对照组相比,间歇性禁食在4周后显著改善左心室喷射率 (P=0.038),在3个月和6个月后持续作用.
- 间歇性禁食的患者经历了更大的腹压血压和体重减轻.
- 间歇性禁食方案表现出很高的坚持 (中位数为83.7%) 并被很好地容忍,没有报告过头或昏迷等不良事件.
结论:
- 间歇性禁食是一种安全且可能有益的饮食干预措施,用于从STEMI中康复的患者.
- IF可能会改善心脏功能,并减少心肌梗塞后的关键心血管风险因素.
- 这些发现支持未来的大规模试验的可行性,研究MI后人群中间歇性禁食.
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