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DNA甲基化及其在炎症性肠病中的应用的影响 (综述)
Francis Atim Akanyibah1, Yi Zhu2, Aijun Wan3
1Department of Laboratory Medicine, Lianyungang Clinical College, Jiangsu University, Lianyungang, Jiangsu 222006, P.R. China.
DNA甲基化 (DNAm) 在炎症性肠病 (IBD) 病原发生过程中起着关键作用. 了解DNAm相关基因为IBD治疗提供了新的诊断,预后和治疗策略.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
- 胃肠病学 胃肠病学
背景情况:
- 炎症性肠病 (IBD) 涉及由遗传,环境,免疫和微生物因素影响的持续性炎症.
- 基因甲基化 (DNAm) 是调节基因转录的关键表观遗传机制,在疾病中越来越多地被研究.
- 一些信号通路,包括IL-23/IL-12和JAK-STAT,涉及IBD病原体,并由DNAm调节.
研究的目的:
- 审查DNA甲基化相关基因在炎症性肠病 (IBD) 的病原发生.
- 总结这些基因作为IBD的诊断,预后和治疗生物标志物的潜力.
- 为IBD管理提供临床决策和治疗替代方案的见解.
主要方法:
- 文献综述专注于DNA甲基化和炎症性肠道疾病.
- 对调查IBD表观遗传修饰的研究进行分析.
- 综合当前关于DNAm相关基因和IBD的途径的知识.
主要成果:
- DNA甲基化与IBD的持续性炎症特征有关.
- 像IL-23/IL-12,Wnt和JAK-STAT信号传输这样的特定途径与DNAm和IBD有关.
- 与DNAm相关的基因有助于IBD炎症的延续.
结论:
- 与DNA甲基化相关的基因代表了IBD的新治疗标.
- 这些基因作为诊断,预测预后和引导IBD治疗的生物标志物具有前景.
- 对IBD特异性甲基基因的进一步研究可以增强临床决策和治疗策略.
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