纳米材料在调节与瘤相关的巨细胞和增强免疫治疗中的作用
Chen Liang1, Yihan Zhang2, Siyao Wang1
1Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences & School of Medicine, Northwest University, Xi'an, Shaanxi 710069, China. liuxiaoli0108@xjtu.edu.cn.
Journal of materials chemistry. B
|May 2, 2024
概括
纳米材料可以将促进瘤的巨细胞 (TAMs) 重编程到抗癌状态,并提供疗法. 这种双重作用通过有效地向瘤微环境来增强癌症免疫疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 纳米医学是一种纳米医学.
背景情况:
- 瘤微环境 (TME) 中的瘤相关巨细胞 (TAM) 通常通过类似M2的表型促进瘤生长.
- 将TAM重定向为类似M1的表型提供了一种增强抗瘤免疫力的策略.
- 目前的TAM调节剂面临着瘤积累和非标效应的挑战.
研究的目的:
- 审查基于纳米材料的策略,以调节TME中的巨细胞极化.
- 探索纳米材料作为输送工具和TAM调节器的双重作用.
- 讨论针对TAM的纳米药物与癌症免疫疗法的组合.
主要方法:
- 关于纳米材料和TAM调制的当前文献的全面审查.
- 分析纳米材料-巨细胞相互作用背后的机制.
- 探索纳米医学在联合癌症免疫治疗中的应用.
主要成果:
- 纳米材料可以被设计为增强药物输送到瘤和调节TAM极化.
- 利用纳米材料-巨细胞相互作用可以将TAM转向抗瘤M1表型.
- 将纳米药物与免疫疗法结合起来,显示出潜在的协同抗癌效应.
结论:
- 纳米材料提供了一个有希望的方法来克服TAM调节癌症疗法的局限性.
- 用纳米材料向TAM可以增强TME内的免疫反应.
- 与免疫疗法相结合的TAM调节纳米药物代表了癌症治疗的新且有效的策略.
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