在英国生物银行中,埃索诺菲尔与癌症风险之间的关联
Jeanny H Wang1, Charles S Rabkin1, Eric A Engels1
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
International journal of cancer
|May 2, 2024
概括
较高的血红蛋白细胞计数与较低的整体癌症风险有关,这表明它在瘤监测中起着保护作用. 这项大型研究分析了超过40万名成年人,并发现许多癌症类型的反向关联.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 乙氨基酸在瘤微环境中的抗瘤反应中发挥作用.
- 乙氨基酸可能有助于身体对癌症发展的监测.
研究的目的:
- 为了研究循环中的乙酸蛋白水平与患各种癌症的风险之间的关联.
- 为了确定氨酸细胞计数是否可以作为癌症发病率的预测标记.
主要方法:
- 分析了443,542名没有癌症的成年人 (年龄在38-73岁之间) 的英国生物库数据.
- 多变量考克斯回归用于估计58种癌症类型中绝对乙酸细胞计数 (AEC) 的危险比率.
- 针对相关混因素进行了调整,随访时间中位数为5.8年.
主要成果:
- 在AEC和整体癌症风险之间发现了反向关联 (aHR:0.97).
- 对血液和非血液癌症 (包括白血病,淋巴瘤,黑色素瘤和乳腺癌) 观察到显著的反向关联.
- 在肝脏内胆道癌症和某些淋巴瘤中发现了增加风险的边界显著关联.
结论:
- 更高的绝对乙氨基细胞计数与整体癌症风险降低有关.
- 乙氨基酸可能在癌症免疫监测中发挥保护作用.
- 这些发现提供了关于血液中乙酸蛋白和广泛的发病癌症之间的关系的见解.
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