复发性绝经后出血:病理发现和预测因素. 一个多中心,前性,观察性研究
Laura D P R van Maldegem1, Johanna A van der Zande1, Lucy A van Werkhoven1
1Department of Gynecologic Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Acta obstetricia et gynecologica Scandinavica
|May 2, 2024
概括
反复出现的绝经后出血 (PMB) 是常见的,与良性息肉有关,而不是更高的癌症风险. 激素替代疗法和初始的息肉预测复发.
科学领域:
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
背景情况:
- 复发性绝经后出血 (PMB) 影响了6%-25%的女性有以前的发作.
- 再发性PMB与子宫内膜癌 (EC) 风险之间的联系仍在争论中.
- 对于复发性PMB的预测因素尚不清楚.
研究的目的:
- 为了确定复发性PMB的发生率.
- 为了比较单次和复发的PMB发作中的病理发现.
- 确定预测复发性PMB的因素.
主要方法:
- 在荷兰进行了一项为期5年的多中心前性队列研究.
- 包括40岁以上的PMB患者接受子宫内膜采样的女性.
- 追溯确定复发性PMB和分析结果.
主要成果:
- 26.4%的女性经历了61个月的PMB复发.
- 复发的PMB与更多的良性息肉 (34.7%vs25.1%) 和较少的恶性瘤 (5.3%vs17.8%) 相关.
- 激素替代疗法 (HRT) 和初始良性息肉预测了复发的PMB.
结论:
- 复发的PMB在女性中经常发生,这些女性以前曾经有过PMB.
- 具有良性初始发现的复发性PMB与较少的恶性瘤和更多的良性息肉有关.
- 第一次PMB的良性息肉预测复发,但不会增加恶性瘤的风险.
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