聚甲基标签装饰使得PTK7向aptamer的瘤透能力大大提高

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Updated: Jun 27, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Yingying Li1, Chi Zhang1, Ting Fu1,2

  • 1The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.

Bioconjugate chemistry
|May 2, 2024
PubMed
概括

聚甲基 (PFA) 装饰增强了体瘤透和细胞吸收,用于向癌症治疗. 最佳的PFA长度至关重要,以避免非特异性细胞结合,并保持aptamer特异性.

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Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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