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在病毒清除之前和之后,与C型肝炎病毒相关的自身免疫:单一中心,前性,观察性研究
Gianfranco Lauletta1, Sebastiano Cicco2, Franco Dammacco3
1Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Polyclinic of Bari, University of Bari "Aldo Moro", Bari, Italy - gianfranco.lauletta@uniba.it.
Minerva medica
|May 2, 2024
概括
直接作用的抗病毒药物可以清除C型肝炎病毒 (HCV),但治疗后可能会持续或出现诸如低温球蛋白和自身抗体之类的自身免疫表现,需要持续监测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 慢性肝炎C病毒 (HCV) 感染通常与自身免疫性疾病有关.
- 直接作用抗病毒药物 (DAA) 为HCV提供了一个新的治疗范式.
研究的目的:
- 预期评估接受DAA治疗的HCV患者的自身免疫特征.
- 在治疗后96周内评估自身免疫标志物和诊断的变化.
主要方法:
- 140名HCV患者的血球蛋白,RF,ANA,ASMA和其他自身抗体监测.
- 查发生在基线和DAA治疗后12,48和96周.
- 根据实验室发现和诊断的自身免疫性疾病对患者进行分组.
主要成果:
- 在基线时,70名患者出现了自身免疫表现,主要是低血球蛋白血症.
- 在治疗后,冰球蛋白在21%的患者中持续存在,自身抗体波动.
- 在病毒清除后,一些患者出现了新的自身免疫性肝病 (AILD) 和其他自身免疫性疾病.
结论:
- 通过DAA的HCV病毒清除可以导致持续或新的自身免疫现象.
- 自体抗体水平动态变化,与现有的或新的AILD相关联.
- 需要进行更长的随访,以评估AILD的发展,冷球蛋白性血管炎和淋巴瘤风险.
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