在怀孕期间进行呼吸道同胞性病毒疫苗接种,以改善婴儿的结果
Emily Wem Phijffer1, Odette de Bruin2,3, Fariba Ahmadizar3
1Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands.
The Cochrane database of systematic reviews
|May 2, 2024
概括
孕产妇呼吸道同胞性病毒 (RSV) 疫苗接种显著减少了婴儿因RSV疾病住院的情况. 虽然对于先天性异常和生长通常是安全的,但对于早产风险需要进一步调查.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 呼吸道同胞病毒 (RSV) 是婴儿下呼吸道感染 (LRTI) 的主要原因之一.
- 母亲RSV接种疫苗是保护婴儿免受严重RSV疾病的有希望的策略.
- 孕产妇RSV疫苗的临床开发取得了快速进展.
研究的目的:
- 评估母体RSV疫苗接种在预防婴儿RSV疾病中的有效性.
- 评估母体RSV疫苗接种的安全性,包括不良妊娠和婴儿结果.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 搜索了多个数据库,直到2023年7月,包括Cochrane,MEDLINE和Embase.
- 包括6个RCT (17,991名孕妇) 将母体RSV疫苗接种与安慰剂进行比较.
主要成果:
- 母亲接种RSV疫苗显著减少了婴儿因实验室确认的RSV疾病住院的情况 (高确定性证据).
- 对于先天性异常或子宫内生长限制,没有发现重大安全问题.
- 对早产的潜在安全信号需要进一步调查;对死产,孕产妇和婴儿死亡的证据是不确定的.
结论:
- 母亲的RSV疫苗接种有效地减少了婴儿RSV住院.
- 目前的证据表明,对于关键的怀孕和婴儿结果,除了早产的潜在信号外,没有重大安全问题.
- 建议进行进一步的大规模RCT和观察性研究,以确认安全性和有效性.
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