在急性冠状动脉综合征患者中通过药物调和发现的药物差异
Sara Ataei1, Behrouz Makki1, Erfan Ayubi2
1Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Naunyn-Schmiedeberg's archives of pharmacology
|May 2, 2024
概括
在急性冠状动脉综合征 (ACS) 患者中,药物不一致是常见的,通常发生在入院期间. 药物调和对于患者安全至关重要,特别是对于那些患有多种疾病和药物的人来说.
科学领域:
- 临床药房 临床药房
- 患者安全 患者安全
- 心脏病学 心脏病学
背景情况:
- 药物错误,包括药物差异,是导致死亡的主要原因.
- 药物不一致经常发生在护理过渡期间,如入院和出院.
- 药物调和对于防止差异和提高患者安全至关重要.
研究的目的:
- 为了确定在急性冠状动脉综合征 (ACS) 患者中通过药物调和发现的药物差异的患病率和类型.
- 调查导致这种患者群体中药物不一致的因素.
主要方法:
- 进行了一项观察性研究,包括280名被送往专门医院的ACS患者.
- 在入院时进行了药物调和,通过患者/护理人员采访收集药物历史,并审查伴随药物的药物.
- 评估了无意中药物差异的数量,类型和相关因素.
主要成果:
- 在ACS患者中,有很大比例的患者 (27.3%) 经历了非故意的药物差异.
- 最常见的差异是遗漏 (39.7%) 和剂量变化 (20.5%).
- 心血管药物,包括抗失脂血症和抗血小板药物,最常涉及.
- 多种潜在疾病和较高的每日药物计数显著增加了差异的几率 (p < 0.05).
结论:
- 在接受药物调整的ACS患者中,药物差异很普遍.
- 不故意的差异对ACS患者构成风险,特别是那些多药和多种并发症患者.
- 对于高风险的ACS患者来说,增加对药物调和的注意力是有必要的,以提高安全性和护理质量.
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